› 3hyz

X-ray diffraction
2.3Å resolution

Crystal structure of Hsp90 with fragment 42-C03

Released:
DOI: 10.2210/pdb3hyz/pdb
PDB entry 3hyz coloured by chain, front view.
PDB entry 3hyz coloured by chain, side view.
PDB entry 3hyz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Barker J, Mather O, Cheng RKY, Palan S, Felicetti B, Whittaker M

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 249 amino acids
Theoretical weight: 27.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 9-236; Coverage: 31%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand 42C 2 x 42C
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21212
Unit cell:
a: 64.49Å b: 89.25Å c: 98.956Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.236 0.305
Expression system: Escherichia coli

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