› 3hzf

X-ray diffraction
2.5Å resolution

Structure of TR-alfa bound to selective thyromimetic GC-1 in C2 space group

Released:
DOI: 10.2210/pdb3hzf/pdb
PDB entry 3hzf coloured by chain, front view.
PDB entry 3hzf coloured by chain, side view.
PDB entry 3hzf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
Bleicher L, Aparicio R, Nunes FM, Martinez L, Gomes Dias SM, Figueira AC, Santos MA, Venturelli WH, da Silva R, Donate PM, Neves FA, Simeoni LA, Baxter JD, Webb P, Skaf MS, Polikarpov I
BMC Struct Biol 8 8 (2008)
PMID: 18237438

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 31.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10827 (Residues: 148-370; Coverage: 46%)
Gene names: EAR7, ERBA1, NR1A1, THRA, THRA1, THRA2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand B72 1 x B72
1 modified residue:
Ligand CAS 4 x CAS

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: C2
Unit cell:
a: 89.799Å b: 78.777Å c: 43.071Å
α: 90° β: 95.17° γ: 90°
R-values:
R R work R free
0.192 0.188 0.263
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.
Huang et al. (2010)
11 more

1 mention without citation

Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled.
Pfaff et al. (2010)