› 3i5n

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.22 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P08581 (Residues: 1048-1350; Coverage: 22%)
Gene name: MET
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand B2D 1 x B2D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 41.977Å b: 43.241Å c: 158.232Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.225 0.267
Expression system: Trichoplusia ni

Quick links

Citations

1 review citation

The Exploration of Chirality for Improved Druggability within the Human Kinome.
Saha et al. (2020)
19 other articles

5 mentions without citation

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
Cancer Genome Atlas Research et al. (2016)
4 more