3idy

X-ray diffraction
3.2Å resolution

Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C2221

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-209095 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Surface protein gp120 Chains: A, G
Molecule details ›
Chains: A, G
Length: 317 amino acids
Theoretical weight: 35.13 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: P04578 (Residues: 83-492; Coverage: 39%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
Fab b13 heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 231 amino acids
Theoretical weight: 24.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Fab b13 light chain Chains: C, L
Molecule details ›
Chains: C, L
Length: 215 amino acids
Theoretical weight: 23.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 106.168Å b: 204.316Å c: 216.886Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.196 0.237
Expression system: Homo sapiens