› 3ihy

X-ray diffraction
2.8Å resolution

Human PIK3C3 crystal structure

Released:
DOI: 10.2210/pdb3ihy/pdb
PDB entry 3ihy coloured by chain, front view.
PDB entry 3ihy coloured by chain, side view.
PDB entry 3ihy coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Siponen MI, Tresaugues L, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Karlberg T, Kotenyova T, Kotzsch A, Kragh Nielsen T, Moche M, Nyman T, Persson C, Roos AK, Sagemark J, Schueler H, Schutz P, Thorsell AG, Van Den Berg S, Weigelt J, Welin M, Wisniewska M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185509 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase catalytic subunit type 3 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 600 amino acids
Theoretical weight: 68.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NEB9 (Residues: 282-879; Coverage: 67%)
Gene names: PIK3C3, VPS34
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P1
Unit cell:
a: 62.297Å b: 96.491Å c: 150.679Å
α: 107.77° β: 91.75° γ: 92.41°
R-values:
R R work R free
0.19 0.187 0.255
Expression system: Escherichia coli

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