› 3ink

X-ray diffraction
2.5Å resolution

UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY

Released:
DOI: 10.2210/pdb3ink/pdb
PDB entry 3ink coloured by chain, front view.
PDB entry 3ink coloured by chain, side view.
PDB entry 3ink coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Response.
McKay DB
Science 257 412-3 (1992)
PMID: 17832837

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158047 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 133 amino acids
Theoretical weight: 15.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P60568 (Residues: 21-153; Coverage: 100%)
Gene name: IL2
Sequence domains: Interleukin 2
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 55.8Å b: 40.1Å c: 33.7Å
α: 90° β: 109.3° γ: 93.2°
R-values:
R R work R free
0.202 0.202 not available
Expression system: Not provided

Quick links

Citations

10 review citations

Lymphocyte responses and cytokines.
Paul et al. (1994)
9 more

12 mentions without citation

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.
Laraia et al. (2015)
11 more