› 3iu5

X-ray diffraction
1.63Å resolution

Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)

Released:
DOI: 10.2210/pdb3iu5/pdb
PDB entry 3iu5 coloured by chain, front view.
PDB entry 3iu5 coloured by chain, side view.
PDB entry 3iu5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein polybromo-1 Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86U86 (Residues: 43-154; Coverage: 7%)
Gene names: BAF180, PB1, PBRM1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P41
Unit cell:
a: 66.96Å b: 66.96Å c: 40.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.204
Expression system: Escherichia coli

Quick links

Citations

245 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
244 more

6 mentions without citation

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites.
Vidler et al. (2012)
5 more