› 3iwx

X-ray diffraction
2.14Å resolution

Crystal structure of cisplatin bound to a human copper chaperone (dimer)

Released:
DOI: 10.2210/pdb3iwx/pdb
PDB entry 3iwx coloured by chain, front view.
PDB entry 3iwx coloured by chain, side view.
PDB entry 3iwx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of cisplatin bound to a human copper chaperone.
Boal AK, Rosenzweig AC
J Am Chem Soc 131 14196-7 (2009)
PMID: 19807176

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126196 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper transport protein ATOX1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 68 amino acids
Theoretical weight: 7.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00244 (Residues: 1-68; Coverage: 100%)
Gene names: ATOX1, HAH1
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

2 bound ligands:
Ligand CPT 1 x CPT
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P65
Unit cell:
a: 78.289Å b: 78.289Å c: 54.335Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.186 0.228
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs.
Howell et al. (2010)
16 more

10 mentions without citation

Crystal structures of cisplatin bound to a human copper chaperone.
Boal et al. (2009)
9 more