› 3iz2

Electron crystallography
10Å resolution

C-alpha model fitted into the EM structure of Cx26M34Adel2-7

Released:
DOI: 10.2210/pdb3iz2/pdb
PDB entry 3iz2 coloured by chain, front view.
PDB entry 3iz2 coloured by chain, side view.
PDB entry 3iz2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels.
Oshima A, Tani K, Toloue MM, Hiroaki Y, Smock A, Inukai S, Cone A, Nicholson BJ, Sosinsky GE, Fujiyoshi Y
J Mol Biol 405 724-35 (2011)
PMID: 21094651
Related structures: EMD-1749

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151334 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction beta-2 protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 232 amino acids
Theoretical weight: 26.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29033 (Residues: 8-226; Coverage: 97%)
Gene name: GJB2
Sequence domains: Connexin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 10Å
Relevant EMDB volumes: EMD-1749
Expression system: Spodoptera frugiperda

Quick links

Citations

19 review citations

Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues.
Márquez-Rosado et al. (2012)
18 more

2 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
1 more