› 3j07

Hybrid

Model of a 24mer alphaB-crystallin multimer

Released:
DOI: 10.2210/pdb3j07/pdb
PDB entry 3j07 coloured by chain, front view.
PDB entry 3j07 coloured by chain, side view.
PDB entry 3j07 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
N-terminal domain of alphaB-crystallin provides a conformational switch for multimerization and structural heterogeneity.
Jehle S, Vollmar BS, Bardiaux B, Dove KK, Rajagopal P, Gonen T, Oschkinat H, Klevit RE
Proc Natl Acad Sci U S A 108 6409-14 (2011)
PMID: 21464278
Related structures: EMD-1776

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-crystallin B chain Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Length: 175 amino acids
Theoretical weight: 20.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02511 (Residues: 1-175; Coverage: 100%)
Gene names: CRYA2, CRYAB, HSPB5
Sequence domains:
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Experimental Method: Solid-state NMR, Electron Microscopy, X-ray solution scattering
Resolution: 20Å
Relevant EMDB volumes: EMD-1776
Expression system: Escherichia coli

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Citations

34 review citations

Large potentials of small heat shock proteins.
Mymrikov et al. (2011)
33 more

9 mentions without citation

Mechanisms of Small Heat Shock Proteins.
Janowska et al. (2019)
8 more