› 3j6c

Electron Microscopy
9.6Å resolution

Cryo-EM structure of MAVS CARD filament

Released:
DOI: 10.2210/pdb3j6c/pdb
PDB entry 3j6c coloured by chain, front view.
PDB entry 3j6c coloured by chain, side view.
PDB entry 3j6c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJ, Borkowski B, Zhang X, Chen ZJ, Jiang QX
Elife 3 e01489 (2014)
PMID: 24569476
Related structures: EMD-5890

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial antiviral-signaling protein Chain: A
Molecule details ›
Chain: A
Length: 93 amino acids
Theoretical weight: 10.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7Z434 (Residues: 3-93; Coverage: 17%)
Gene names: IPS1, KIAA1271, MAVS, VISA
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 9.6Å
Relevant EMDB volumes: EMD-5890
Expression system: Homo sapiens

Quick links

Citations

40 review citations

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5.
Reikine et al. (2014)
39 more

4 mentions without citation

The role of the interactome in the maintenance of deleterious variability in human populations.
Garcia-Alonso et al. (2014)
3 more