› 3j6j

Electron Microscopy
3.64Å resolution

3.6 Angstrom resolution MAVS filament generated from helical reconstruction

Released:
DOI: 10.2210/pdb3j6j/pdb
PDB entry 3j6j coloured by chain, front view.
PDB entry 3j6j coloured by chain, side view.
PDB entry 3j6j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.
Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S
Mol Cell 55 511-23 (2014)
PMID: 25018021
Related structures: EMD-5925

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182264 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial antiviral-signaling protein Chains: A, B, C, D, E, G, I, L
Molecule details ›
Chains: A, B, C, D, E, G, I, L
Length: 97 amino acids
Theoretical weight: 11.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z434 (Residues: 1-97; Coverage: 18%)
Gene names: IPS1, KIAA1271, MAVS, VISA
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.64Å
Relevant EMDB volumes: EMD-5925
Expression system: Escherichia coli

Quick links

Citations

58 review citations

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.
Wu et al. (2016)
57 more

10 mentions without citation

International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.
Bryant et al. (2015)
9 more