› 3j70

Electron Microscopy
20Å resolution

Model of gp120, including variable regions, in complex with CD4 and 17b

Released:
DOI: 10.2210/pdb3j70/pdb
PDB entry 3j70 coloured by chain, front view.
PDB entry 3j70 coloured by chain, side view.
PDB entry 3j70 coloured by chain, top view.
Source organisms:
Primary publication:
Computational Refinement and Validation Protocol for Proteins with Large Variable Regions Applied to Model HIV Env Spike in CD4 and 17b Bound State.
Rasheed M, Bettadapura R, Bajaj C
Structure 23 1138-49 (2015)
PMID: 26039348
Related structures: EMD-5020

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
PDBe Complex ID:
PDB-CPX-208509 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
monoclonal antibody 17b light chain Chains: A, M, R
Molecule details ›
Chains: A, M, R
Length: 212 amino acids
Theoretical weight: 22.64 KDa
Source organism: Homo sapiens
monoclonal antibody 17b heavy chain Chains: B, N, S
Molecule details ›
Chains: B, N, S
Length: 210 amino acids
Theoretical weight: 22.82 KDa
Source organism: Homo sapiens
T-cell surface glycoprotein CD4 Chains: C, O, T
Molecule details ›
Chains: C, O, T
Length: 185 amino acids
Theoretical weight: 20.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01730 (Residues: 26-208; Coverage: 42%)
Gene name: CD4
Sequence domains:
Surface protein gp120 Chains: D, P, U
Molecule details ›
Chains: D, P, U
Length: 470 amino acids
Theoretical weight: 52.57 KDa
Source organism: Human immunodeficiency virus 1
UniProt:
  • Canonical: P04578 (Residues: 31-500; Coverage: 57%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
envelope glycoprotein gp41 Chains: E, Q, V
Molecule details ›
Chains: E, Q, V
Length: 140 amino acids
Theoretical weight: 11.93 KDa
Source organism: Human immunodeficiency virus 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 20Å
Relevant EMDB volumes: EMD-5020

Quick links

Citations

2 review citations

Survivors Remorse: antibody-mediated protection against HIV-1.
Lewis et al. (2017)
1 more

18 mentions without citation

Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide Design.
Düzgüneş et al. (2021)
17 more