› 3jqz

X-ray diffraction
3.3Å resolution

Crystal Structure of Human serum albumin complexed with Lidocaine

Released:
DOI: 10.2210/pdb3jqz/pdb
PDB entry 3jqz coloured by chain, front view.
PDB entry 3jqz coloured by chain, side view.
PDB entry 3jqz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin.
Hein KL, Kragh-Hansen U, Morth JP, Jeppesen MD, Otzen D, Møller JV, Nissen P
J Struct Biol 171 353-60 (2010)
PMID: 20347991

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136187 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand LQZ 1 x LQZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: I41
Unit cell:
a: 168.476Å b: 168.476Å c: 97.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.22 0.268
Expression system: Komagataella pastoris

Quick links

Citations

8 review citations

Albumin-drug interaction and its clinical implication.
Yamasaki et al. (2013)
7 more

5 mentions without citation

Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties.
Belinskaia et al. (2021)
4 more