› 3js2

X-ray diffraction
2.2Å resolution

Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with 5-(2-thienyl)nicotinic acid

Released:
DOI: 10.2210/pdb3js2/pdb
PDB entry 3js2 coloured by chain, front view.
PDB entry 3js2 coloured by chain, side view.
PDB entry 3js2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening.
Ravindranathan KP, Mandiyan V, Ekkati AR, Bae JH, Schlessinger J, Jorgensen WL
J Med Chem 53 1662-72 (2010)
PMID: 20121196

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 36.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11362 (Residues: 458-765; Coverage: 39%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand VM1 2 x VM1
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 207.799Å b: 58.304Å c: 66.248Å
α: 90° β: 107.36° γ: 90°
R-values:
R R work R free
0.216 0.216 0.259
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Computational methods in drug discovery.
Sliwoski et al. (2014)
5 more

6 mentions without citation

Structural studies of CNG repeats.
Kiliszek et al. (2014)
5 more