› 3jyh

X-ray diffraction
2.19Å resolution

Human dipeptidyl peptidase DPP7

Released:
DOI: 10.2210/pdb3jyh/pdb
PDB entry 3jyh coloured by chain, front view.
PDB entry 3jyh coloured by chain, side view.
PDB entry 3jyh coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dobrovetsky E, Dong A, Seitova A, Crombett L, Paganon S, Cossar D, Edwards AM, Arrowsmith CH, Bountra C, Weigelt J, Hassel A, Shewchuk L, Bochkarev A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193754 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Dipeptidyl peptidase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 469 amino acids
Theoretical weight: 52.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UHL4 (Residues: 28-492; Coverage: 99%)
Gene names: DPP2, DPP7, QPP
Sequence domains: Serine carboxypeptidase S28
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 80.216Å b: 130.215Å c: 124.436Å
α: 90° β: 102.36° γ: 90°
R-values:
R R work R free
0.182 0.18 0.222
Expression system: Spodoptera frugiperda

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