› 3jzn

X-ray diffraction
2.6Å resolution

Structure of EED in apo form

Released:
DOI: 10.2210/pdb3jzn/pdb
PDB entry 3jzn coloured by chain, front view.
PDB entry 3jzn coloured by chain, side view.
PDB entry 3jzn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, MacKenzie F, Pan P, Li SS, Wang H, Min J
Proc Natl Acad Sci U S A 107 19266-71 (2010)
PMID: 20974918

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycomb protein EED Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 42.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75530 (Residues: 76-441; Coverage: 83%)
Gene name: EED
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 57.64Å b: 85.159Å c: 91.327Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.172 0.239
Expression system: Escherichia coli

Quick links

Citations

52 review citations

Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put.
Simon et al. (2013)
51 more

2 mentions without citation

Readers of histone modifications.
Yun et al. (2011)
1 more