› 3jzq

X-ray diffraction
1.8Å resolution

Human MDMX liganded with a 12mer peptide inhibitor (pDIQ)

Released:
DOI: 10.2210/pdb3jzq/pdb
PDB entry 3jzq coloured by chain, front view.
PDB entry 3jzq coloured by chain, side view.
PDB entry 3jzq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
Phan J, Li Z, Kasprzak A, Li B, Sebti S, Guida W, Schönbrunn E, Chen J
J Biol Chem 285 2174-83 (2010)
PMID: 19910468

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127320 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 89 amino acids
Theoretical weight: 10.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15151 (Residues: 23-111; Coverage: 18%)
Gene names: MDM4, MDMX
Structure domains: SWIB/MDM2 domain
pDIQ peptide (12mer) Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 12 amino acids
Theoretical weight: 1.56 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 44.925Å b: 53.735Å c: 87.294Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.224
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

12 review citations

Drugging the p53 pathway: understanding the route to clinical efficacy.
Khoo et al. (2014)
11 more

6 mentions without citation

How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures.
Estrada-Ortiz et al. (2016)
5 more