Function and Biology Details
Reaction catalysed:
Similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Procathepsin L and peptide (preferred)
PDBe Complex ID:
PDB-CPX-139721 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Cathepsin L
Molecule details ›
Chains: A, B
Length: 220 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases
Length: 220 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
- Canonical:
P07711 (Residues: 114-333; Coverage: 70%)
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases
Ligands and Environments
1 bound ligand:
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 23-ID-B
Spacegroup:
P3221
Expression systems:
- Komagataella pastoris
- Not provided
