› 3k2j

X-ray diffraction
2.2Å resolution

Crystal Structure of the 3rd Bromodomain of Human Poly-bromodomain containing protein 1 (PB1)

Released:
DOI: 10.2210/pdb3k2j/pdb
PDB entry 3k2j coloured by chain, front view.
PDB entry 3k2j coloured by chain, side view.
PDB entry 3k2j coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Picaud S, Keates T, Chaikuad A, Pike ACW, Krojer T, Sethi R, von Delft F, Arrowsmith CH, Edwards A, Weigelt J, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183178 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein polybromo-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 130 amino acids
Theoretical weight: 15.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86U86 (Residues: 388-494; Coverage: 6%)
Gene names: BAF180, PB1, PBRM1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P65
Unit cell:
a: 81.39Å b: 81.39Å c: 79.475Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.224 0.27
Expression system: Escherichia coli

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