› 3k2s

X-ray solution scattering

Solution structure of double super helix model

Released:
DOI: 10.2210/pdb3k2s/pdb
PDB entry 3k2s coloured by chain, front view.
PDB entry 3k2s coloured by chain, side view.
PDB entry 3k2s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Double superhelix model of high density lipoprotein.
Wu Z, Gogonea V, Lee X, Wagner MA, Li XM, Huang Y, Undurti A, May RP, Haertlein M, Moulin M, Gutsche I, Zaccai G, DiDonato JA, Hazen SL
J Biol Chem 284 36605-36619 (2009)
PMID: 19812036

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein A-I Chains: A, B
Molecule details ›
Chains: A, B
Length: 243 amino acids
Theoretical weight: 28.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02647 (Residues: 25-267; Coverage: 98%)
Gene name: APOA1
Sequence domains: Apolipoprotein A1/A4/E domain

Ligands and Environments

2 bound ligands:
Ligand POV 200 x POV
Ligand CLR 20 x CLR
No modified residues

Experiments and Validation Details

Expression system: Escherichia coli

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Citations

14 review citations

HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms.
Navab et al. (2011)
13 more

9 mentions without citation

Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma.
Huang et al. (2011)
8 more