› 3k8s

X-ray diffraction
2.55Å resolution

Crystal Structure of PPARg in complex with T2384

Released:
DOI: 10.2210/pdb3k8s/pdb
PDB entry 3k8s coloured by chain, front view.
PDB entry 3k8s coloured by chain, side view.
PDB entry 3k8s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties.
Li Y, Wang Z, Furukawa N, Escaron P, Weiszmann J, Lee G, Lindstrom M, Liu J, Liu X, Xu H, Plotnikova O, Prasad V, Walker N, Learned RM, Chen JL
J Biol Chem 283 9168-76 (2008)
PMID: 18263587

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 272 amino acids
Theoretical weight: 31.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 234-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand Z27 3 x Z27
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 91.553Å b: 62.396Å c: 118.943Å
α: 90° β: 102.63° γ: 90°
R-values:
R R work R free
0.226 0.226 0.273
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The role of peroxisome proliferator-activated receptors (PPAR) in immune responses.
Christofides et al. (2021)
4 more

10 mentions without citation

Review of the Structural and Dynamic Mechanisms of PPARĪ³ Partial Agonism.
Kroker et al. (2015)
9 more