› 3k9l

X-ray diffraction
1.8Å resolution

Allosteric modulation of H-Ras GTPase

Released:
DOI: 10.2210/pdb3k9l/pdb
PDB entry 3k9l coloured by chain, front view.
PDB entry 3k9l coloured by chain, side view.
PDB entry 3k9l coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Fetics S, Young M, Buhrman G, Mattos C

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133956 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase HRas, N-terminally processed Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 166 amino acids
Theoretical weight: 18.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01112 (Residues: 1-166; Coverage: 88%)
Gene names: HRAS, HRAS1
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
Ligand CA 2 x CA
Ligand MG 3 x MG
Ligand GNP 3 x GNP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 95.113Å b: 60.632Å c: 74.975Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.219 0.271
Expression system: Escherichia coli

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