› 3kfc

X-ray diffraction
2.4Å resolution

Complex Structure of LXR with an agonist

Released:
DOI: 10.2210/pdb3kfc/pdb
PDB entry 3kfc coloured by chain, front view.
PDB entry 3kfc coloured by chain, side view.
PDB entry 3kfc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.
Bernotas RC, Singhaus RR, Kaufman DH, Travins JM, Ullrich JW, Unwalla R, Quinet E, Evans M, Nambi P, Olland A, Kauppi B, Wilhelmsson A, Goos-Nilsson A, Wrobel J
Bioorg Med Chem Lett 20 209-12 (2010)
PMID: 19932617

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 253 amino acids
Theoretical weight: 29.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55055 (Residues: 212-460; Coverage: 54%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 61X 3 x 61X
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 58.993Å b: 99.286Å c: 174.962Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.238 0.284
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Liver X receptor modulators: a review of recently patented compounds (2007 - 2009).
Li et al. (2010)
1 more

5 mentions without citation

Ligands of Therapeutic Utility for the Liver X Receptors.
Komati et al. (2017)
4 more