› 3kgr

X-ray diffraction
1.8Å resolution

Crystal structure of the human leukocyte-associated Ig-like receptor-1 (LAIR-1)

Released:
DOI: 10.2210/pdb3kgr/pdb
PDB entry 3kgr coloured by chain, front view.
PDB entry 3kgr coloured by chain, side view.
PDB entry 3kgr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI.
Brondijk TH, de Ruiter T, Ballering J, Wienk H, Lebbink RJ, van Ingen H, Boelens R, Farndale RW, Meyaard L, Huizinga EG
Blood 115 1364-73 (2010)
PMID: 20007810

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179712 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukocyte-associated immunoglobulin-like receptor 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 106 amino acids
Theoretical weight: 11.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6GTX8 (Residues: 22-122; Coverage: 38%)
Gene names: CD305, LAIR1
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand GLY 1 x GLY
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P32
Unit cell:
a: 69.395Å b: 69.395Å c: 54.258Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.124 0.123 0.157
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The collagen family.
Ricard-Blum S. (2011)
10 more

6 mentions without citation

The structural basis of ligand recognition by natural killer cell receptors.
Joyce et al. (2011)
5 more