› 3kid

X-ray diffraction
2.71Å resolution

The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator

Released:
DOI: 10.2210/pdb3kid/pdb
PDB entry 3kid coloured by chain, front view.
PDB entry 3kid coloured by chain, side view.
PDB entry 3kid coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
Jiang L-G, Yu H-Y, Yuan C, Wang J-D, Chen L-Q, Meehan EJ, Huang Z-X, Huang M-D
Chin. J. Struct. Chem. 28 1427-1432 (2009)

Function and Biology Details

Reaction catalysed: 
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urokinase-type plasminogen activator chain B Chain: U
Molecule details ›
Chain: U
Length: 253 amino acids
Theoretical weight: 28.44 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P00749 (Residues: 179-431; Coverage: 62%)
Gene name: PLAU
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand 2BS 1 x 2BS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: R3
Unit cell:
a: 121.216Å b: 121.216Å c: 43.299Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.223 0.275
Expression system: Komagataella pastoris

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