› 3kls

X-ray diffraction
3.6Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133872 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1676 amino acids
Theoretical weight: 188.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01031 (Residues: 1-1676; Coverage: 100%)
Gene names: C5, CPAMD4
Sequence domains:
Structure domains:
Exotoxin 1 Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 231 amino acids
Theoretical weight: 26.01 KDa
Source organism: Staphylococcus aureus subsp. aureus MRSA252
Expression system: Escherichia coli
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand CD 9 x CD
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P31
Unit cell:
a: 143.875Å b: 143.875Å c: 241.24Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.198 0.263
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Neutrophils versus Staphylococcus aureus: a biological tug of war.
Spaan et al. (2013)
12 more

2 mentions without citation

Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.
Laursen et al. (2010)
1 more