› 3kn6

X-ray diffraction
2Å resolution

Crystal structure of the C-terminal kinase domain of MSK1

Released:
DOI: 10.2210/pdb3kn6/pdb
PDB entry 3kn6 coloured by chain, front view.
PDB entry 3kn6 coloured by chain, side view.
PDB entry 3kn6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
Malakhova M, D'Angelo I, Kim HG, Kurinov I, Bode AM, Dong Z
J Mol Biol 399 41-52 (2010)
PMID: 20382163

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131072 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 325 amino acids
Theoretical weight: 37.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75582 (Residues: 414-738; Coverage: 41%)
Gene names: MSK1, RPS6KA5
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 51.386Å b: 91.739Å c: 134.945Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.216 0.263
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Gógl et al. (2019)
3 other articles

5 mentions without citation

The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancer.
Acuner Ozbabacan et al. (2014)
4 more