Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Ras guanine-nucleotide exchange factors catalytic domain
- Ras-like guanine nucleotide exchange factor, N-terminal
- Dbl homology (DH) domain
- Pleckstrin homology domain
- Dbl homology (DH) domain superfamily
- Histone-fold
- Ras guanine-nucleotide exchange factor, conserved site
- Ras guanine-nucleotide exchange factor, catalytic domain superfamily
3 more domains
Structure analysis Details
Assemblies composition:
Assembly name:
Son of sevenless homolog 1 (preferred)
PDBe Complex ID:
PDB-CPX-170560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Son of sevenless homolog 1
Molecule details ›
Chain: A
Length: 1049 amino acids
Theoretical weight: 121.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 1049 amino acids
Theoretical weight: 121.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q07889 (Residues: 1-1049; Coverage: 79%)
Sequence domains:
Structure domains:
- Histone, subunit A
- Dbl homology (DH) domain
- Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
- Single alpha-helices involved in coiled-coils or other helix-helix interfaces
- Son of sevenless (SoS) protein Chain: S domain 1
- Ras guanine-nucleotide exchange factors catalytic domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.2.2
Spacegroup:
C2221
Expression system: Escherichia coli
