› 3ktf

X-ray diffraction
1.6Å resolution

Structure of the N-terminal BRCT domain of human microcephalin (MCPH1).

Released:
DOI: 10.2210/pdb3ktf/pdb
PDB entry 3ktf coloured by chain, front view.
PDB entry 3ktf coloured by chain, side view.
PDB entry 3ktf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Singh N, Heroux A, Thompson JR, Mer G

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microcephalin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 103 amino acids
Theoretical weight: 11.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NEM0 (Residues: 1-101; Coverage: 12%)
Gene name: MCPH1
Sequence domains: twin BRCT domain
Structure domains: BRCT domain

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 35.069Å b: 39.274Å c: 106.639Å
α: 90° β: 91.52° γ: 90°
R-values:
R R work R free
0.139 0.138 0.195
Expression system: Escherichia coli

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