› 3kvq

X-ray diffraction
2.7Å resolution

Crystal structure of VEGFR2 extracellular domain D7

Released:
DOI: 10.2210/pdb3kvq/pdb
PDB entry 3kvq coloured by chain, front view.
PDB entry 3kvq coloured by chain, side view.
PDB entry 3kvq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling.
Yang Y, Xie P, Opatowsky Y, Schlessinger J
Proc Natl Acad Sci U S A 107 1906-11 (2010)
PMID: 20080685

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 11.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35968 (Residues: 657-764; Coverage: 8%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: I212121
Unit cell:
a: 39.476Å b: 76.989Å c: 102.035Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.23 0.296
Expression system: Escherichia coli

Quick links

Citations

17 review citations

The lymphatic vasculature in disease.
Alitalo K. (2011)
16 more

11 mentions without citation

Function of members of the neuropilin family as essential pleiotropic cell surface receptors.
Parker et al. (2012)
10 more