› 3kxu

X-ray diffraction
1.85Å resolution

Crystal structure of human ferritin FTL498InsTC pathogenic mutant

Released:
DOI: 10.2210/pdb3kxu/pdb
PDB entry 3kxu coloured by chain, front view.
PDB entry 3kxu coloured by chain, side view.
PDB entry 3kxu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation.
Luscieti S, Santambrogio P, Langlois d'Estaintot B, Granier T, Cozzi A, Poli M, Gallois B, Finazzi D, Cattaneo A, Levi S, Arosio P
J Biol Chem 285 11948-57 (2010)
PMID: 20159981

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136239 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin light chain Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02792 (Residues: 1-172; Coverage: 98%)
Gene name: FTL
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

2 bound ligands:
Ligand CD 12 x CD
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: I432
Unit cell:
a: 151.355Å b: 151.355Å c: 151.355Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.179 0.211
Expression system: Escherichia coli

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Citations

13 review citations

Mammalian iron metabolism and its control by iron regulatory proteins.
Anderson et al. (2012)
12 more