› 3kxx

X-ray diffraction
3.2Å resolution

Structure of the mutant Fibroblast Growth Factor receptor 1

Released:
DOI: 10.2210/pdb3kxx/pdb
PDB entry 3kxx coloured by chain, front view.
PDB entry 3kxx coloured by chain, side view.
PDB entry 3kxx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Bae JH, Boggon TJ, Tomé F, Mandiyan V, Lax I, Schlessinger J
Proc Natl Acad Sci U S A 107 2866-71 (2010)
PMID: 20133753

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 317 amino acids
Theoretical weight: 36.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11362 (Residues: 458-765; Coverage: 39%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 186.801Å b: 74.29Å c: 135.776Å
α: 90° β: 97.41° γ: 90°
R-values:
R R work R free
0.224 0.222 0.263
Expression system: Escherichia coli

Quick links

Citations

14 review citations

A structural perspective on the regulation of the epidermal growth factor receptor.
Kovacs et al. (2015)
13 more

2 mentions without citation

Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Bae et al. (2010)
1 more