› 3kzj

X-ray diffraction
1.65Å resolution

Structure of complement Factor H variant R1203A

Released:
DOI: 10.2210/pdb3kzj/pdb
PDB entry 3kzj coloured by chain, front view.
PDB entry 3kzj coloured by chain, side view.
PDB entry 3kzj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d.
Bhattacharjee A, Lehtinen MJ, Kajander T, Goldman A, Jokiranta TS
Mol Immunol 47 1686-91 (2010)
PMID: 20378178

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140221 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.01 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08603 (Residues: 1103-1231; Coverage: 11%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: I4122
Unit cell:
a: 91.41Å b: 91.41Å c: 110.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.203 0.222
Expression system: Komagataella pastoris

Quick links

Citations

6 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
5 more

1 mention without citation

The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease.
Bhattacharjee et al. (2015)