› 3l5h

X-ray diffraction
3.6Å resolution

Crystal structure of the full ectodomain of human gp130: New insights into the molecular assembly of receptor complexes

Released:
DOI: 10.2210/pdb3l5h/pdb
PDB entry 3l5h coloured by chain, front view.
PDB entry 3l5h coloured by chain, side view.
PDB entry 3l5h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes.
Xu Y, Kershaw NJ, Luo CS, Soo P, Pocock MJ, Czabotar PE, Hilton DJ, Nicola NA, Garrett TP, Zhang JG
J Biol Chem 285 21214-8 (2010)
PMID: 20489211

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154044 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Interleukin-6 receptor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 589 amino acids
Theoretical weight: 67.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P40189 (Residues: 24-612; Coverage: 66%)
Gene name: IL6ST
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 89.001Å b: 51.821Å c: 167.157Å
α: 90° β: 102.17° γ: 90°
R-values:
R R work R free
0.267 0.263 0.335
Expression system: Spodoptera frugiperda

Quick links

Citations

13 review citations

The pro- and anti-inflammatory properties of the cytokine interleukin-6.
Scheller et al. (2011)
12 more

16 mentions without citation

Leukemia inhibitory factor (LIF).
Nicola et al. (2015)
15 more