› 3l6a

X-ray diffraction
2Å resolution

Crystal structure of the C-terminal region of Human p97

Released:
DOI: 10.2210/pdb3l6a/pdb
PDB entry 3l6a coloured by chain, front view.
PDB entry 3l6a coloured by chain, side view.
PDB entry 3l6a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the C-terminal region of human p97/DAP5.
Fan S, Jia MZ, Gong W
Proteins 78 2385-90 (2010)
PMID: 20544972

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 4 gamma 2 Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78344 (Residues: 540-897; Coverage: 40%)
Gene names: DAP5, EIF4G2, OK/SW-cl.75
Sequence domains:
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

4 bound ligands:
Ligand MES 2 x MES
Ligand PG4 2 x PG4
Ligand PEG 1 x PEG
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A, RIGAKU
Spacegroup: P212121
Unit cell:
a: 31.084Å b: 102.27Å c: 112.973Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.2 0.25
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Translation initiation by cap-dependent ribosome recruitment: Recent insights and open questions.
Shirokikh et al. (2018)
1 more

2 mentions without citation

The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation.
Friedrich et al. (2022)
1 more