› 3lbd

X-ray diffraction
2.4Å resolution

LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID

Released:
DOI: 10.2210/pdb3lbd/pdb
PDB entry 3lbd coloured by chain, front view.
PDB entry 3lbd coloured by chain, side view.
PDB entry 3lbd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational adaptation of agonists to the human nuclear receptor RAR gamma.
Klaholz BP, Renaud JP, Mitschler A, Zusi C, Chambon P, Gronemeyer H, Moras D
Nat Struct Biol 5 199-202 (1998)
PMID: 9501913

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 30.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13631 (Residues: 178-423; Coverage: 54%)
Gene names: NR1B3, RARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 9CR 1 x 9CR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: P41212
Unit cell:
a: 60.666Å b: 60.666Å c: 155.134Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.172 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

Principles for modulation of the nuclear receptor superfamily.
Gronemeyer et al. (2004)
18 more

11 mentions without citation

Retinoic acid actions through mammalian nuclear receptors.
Huang et al. (2014)
10 more