› 3lco

X-ray diffraction
3.4Å resolution

Inhibitor Bound to A DFG-Out structure of the Kinase Domain of CSF-1R

Released:
DOI: 10.2210/pdb3lco/pdb
PDB entry 3lco coloured by chain, front view.
PDB entry 3lco coloured by chain, side view.
PDB entry 3lco coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Meyers MJ, Pelc M, Kamtekar S, Day J, Poda GI, Hall MK, Michener ML, Reitz BA, Mathis KJ, Pierce BS, Parikh MD, Mischke DA, Long SA, Parlow JJ, Anderson DR, Thorarensen A
Bioorg Med Chem Lett 20 1543-7 (2010)
PMID: 20137931

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139513 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07333 (Residues: 550-919; Coverage: 34%)
Gene names: CSF1R, FMS
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand LC0 1 x LC0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P43212
Unit cell:
a: 62.916Å b: 62.916Å c: 183.943Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.245 0.289
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

c-FMS inhibitors: a patent review.
Burns et al. (2011)
4 more

7 mentions without citation

Determining Cysteines Available for Covalent Inhibition Across the Human Kinome.
Zhao et al. (2017)
6 more