› 3ljw

X-ray diffraction
1.5Å resolution

Crystal Structure of the Second Bromodomain of Human Polybromo

Released:
DOI: 10.2210/pdb3ljw/pdb
PDB entry 3ljw coloured by chain, front view.
PDB entry 3ljw coloured by chain, side view.
PDB entry 3ljw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2.
Charlop-Powers Z, Zeng L, Zhang Q, Zhou MM
Cell Res 20 529-38 (2010)
PMID: 20368734

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein polybromo-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 120 amino acids
Theoretical weight: 13.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86U86 (Residues: 174-293; Coverage: 7%)
Gene names: BAF180, PB1, PBRM1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand ACT 2 x ACT
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P31
Unit cell:
a: 78.964Å b: 78.964Å c: 50.651Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.173 0.196
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Readers of histone modifications.
Yun et al. (2011)
14 more

5 mentions without citation

Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome.
Wagner et al. (2020)
4 more