› 3llp

X-ray diffraction
1.8Å resolution

1.8 Angstrom human fascin 1 crystal structure

Released:
DOI: 10.2210/pdb3llp/pdb
PDB entry 3llp coloured by chain, front view.
PDB entry 3llp coloured by chain, side view.
PDB entry 3llp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Migrastatin analogues target fascin to block tumour metastasis.
Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY
Nature 464 1062-6 (2010)
PMID: 20393565

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172542 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fascin Chains: A, B
Molecule details ›
Chains: A, B
Length: 493 amino acids
Theoretical weight: 54.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q16658 (Residues: 1-493; Coverage: 100%)
Gene names: FAN1, FSCN1, HSN, SNL
Sequence domains: Fascin domain
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

5 bound ligands:
Ligand GOL 5 x GOL
Ligand K 2 x K
Ligand BR 7 x BR
Ligand EPE 1 x EPE
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: C2
Unit cell:
a: 159.789Å b: 72.659Å c: 110.142Å
α: 90° β: 130.28° γ: 90°
R-values:
R R work R free
0.175 0.172 0.22
Expression system: Escherichia coli BL21

Quick links

Citations

29 review citations

Tumor metastasis: molecular insights and evolving paradigms.
Valastyan et al. (2011)
28 more

11 mentions without citation

How does fascin promote cancer metastasis?
Lin et al. (2020)
10 more