› 3lo1

X-ray diffraction
1.6Å resolution

Crystal structure of human alpha-defensin 1 (Y16A mutant)

Released:
DOI: 10.2210/pdb3lo1/pdb
PDB entry 3lo1 coloured by chain, front view.
PDB entry 3lo1 coloured by chain, side view.
PDB entry 3lo1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Trp-26 imparts functional versatility to human alpha-defensin HNP1.
Wei G, Pazgier M, de Leeuw E, Rajabi M, Li J, Zou G, Jung G, Yuan W, Lu WY, Lehrer RI, Lu W
J Biol Chem 285 16275-85 (2010)
PMID: 20220136

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil defensin 1 Chain: A
Molecule details ›
Chain: A
Length: 30 amino acids
Theoretical weight: 3.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P59665 (Residues: 65-94; Coverage: 40%)
Gene names: DEF1, DEFA1, DEFA1B, DEFA2, MRS
Sequence domains: Mammalian defensin

Ligands and Environments

2 bound ligands:
Ligand PG0 1 x PG0
Ligand AZI 2 x AZI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C222
Unit cell:
a: 33.463Å b: 74.649Å c: 25.866Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.225
Expression system: Not provided

Quick links

Citations

9 review citations

α-Defensins in human innate immunity.
Lehrer et al. (2012)
8 more

1 mention without citation

Trp-26 imparts functional versatility to human alpha-defensin HNP1.
Wei et al. (2010)