› 3lo2

X-ray diffraction
1.56Å resolution

Crystal structure of human alpha-defensin 1 (Y21A mutant)

Released:
DOI: 10.2210/pdb3lo2/pdb
PDB entry 3lo2 coloured by chain, front view.
PDB entry 3lo2 coloured by chain, side view.
PDB entry 3lo2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Trp-26 imparts functional versatility to human alpha-defensin HNP1.
Wei G, Pazgier M, de Leeuw E, Rajabi M, Li J, Zou G, Jung G, Yuan W, Lu WY, Lehrer RI, Lu W
J Biol Chem 285 16275-85 (2010)
PMID: 20220136

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157837 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil defensin 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 30 amino acids
Theoretical weight: 3.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P59665 (Residues: 65-94; Coverage: 40%)
Gene names: DEF1, DEFA1, DEFA1B, DEFA2, MRS
Sequence domains: Mammalian defensin

Ligands and Environments

3 bound ligands:
Ligand MPD 2 x MPD
Ligand TFA 1 x TFA
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21212
Unit cell:
a: 43.675Å b: 29.882Å c: 41.552Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.2
Expression system: Not provided

Quick links

Citations

9 review citations

α-Defensins in human innate immunity.
Lehrer et al. (2012)
8 more

1 mention without citation

Trp-26 imparts functional versatility to human alpha-defensin HNP1.
Wei et al. (2010)