› 3lqm

X-ray diffraction
2.14Å resolution

Structure of the IL-10R2 Common Chain

Released:
DOI: 10.2210/pdb3lqm/pdb
PDB entry 3lqm coloured by chain, front view.
PDB entry 3lqm coloured by chain, side view.
PDB entry 3lqm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and mechanism of receptor sharing by the IL-10R2 common chain.
Yoon SI, Jones BC, Logsdon NJ, Harris BD, Deshpande A, Radaeva S, Halloran BA, Gao B, Walter MR
Structure 18 638-48 (2010)
PMID: 20462497

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170633 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-10 receptor subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 201 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q08334 (Residues: 20-220; Coverage: 66%)
Gene names: CRFB4, D21S58, D21S66, IL10RB
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 10 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6
Unit cell:
a: 124.839Å b: 124.839Å c: 84.223Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.21 0.239
Expression system: Spodoptera frugiperda

Quick links

Citations

25 review citations

Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Ouyang et al. (2011)
24 more

10 mentions without citation

Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors.
Cai et al. (2022)
9 more