› 3lra

X-ray diffraction
2.95Å resolution

Structural Basis for Assembling a Human Tripartite Complex Dlg1-MPP7-Mals3

Released:
DOI: 10.2210/pdb3lra/pdb
PDB entry 3lra coloured by chain, front view.
PDB entry 3lra coloured by chain, side view.
PDB entry 3lra coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for tandem L27 domain-mediated polymerization.
Yang X, Xie X, Chen L, Zhou H, Wang Z, Zhao W, Tian R, Zhang R, Tian C, Long J, Shen Y
FASEB J 24 4806-15 (2010)
PMID: 20702775

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171454 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 1; MAGUK p55 subfamily member 7; Protein lin-7 homolog C Chain: A
Molecule details ›
Chain: A
Length: 254 amino acids
Theoretical weight: 29.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12959 (Residues: 2-70, 75-75; Coverage: 8%)
  • Canonical: Q5T2T1 (Residues: 4-7, 9-120, 121-123, 124-124; Coverage: 21%)
  • Canonical: Q9NUP9 (Residues: 3-64; Coverage: 32%)
Gene names: DLG1, LIN7C, MALS3, MPP7, VELI3
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A, APS BEAMLINE 19-ID
Spacegroup: P6222
Unit cell:
a: 153.19Å b: 153.19Å c: 58.903Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.257 0.255 0.284
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Event inference in multidomain families with phylogenetic reconciliation.
Stolzer et al. (2015)
4 more

4 mentions without citation

Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module.
Ghosh et al. (2018)
3 more