› 3lre

X-ray diffraction
2.2Å resolution

Crystal Structure Analysis of Human Kinesin-8 Motor Domain

Released:
DOI: 10.2210/pdb3lre/pdb
PDB entry 3lre coloured by chain, front view.
PDB entry 3lre coloured by chain, side view.
PDB entry 3lre coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insight into the molecular mechanism of the multitasking kinesin-8 motor.
Peters C, Brejc K, Belmont L, Bodey AJ, Lee Y, Yu M, Guo J, Sakowicz R, Hartman J, Moores CA
EMBO J 29 3437-47 (2010)
PMID: 20818331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-185574 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF18A Chains: A, B
Molecule details ›
Chains: A, B
Length: 355 amino acids
Theoretical weight: 39.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NI77 (Residues: 1-355; Coverage: 40%)
Gene names: KIF18A, OK/SW-cl.108
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand ADP 2 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P212121
Unit cell:
a: 69.42Å b: 79.744Å c: 140.145Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.277
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Kinesins and cancer.
Rath et al. (2012)
9 more

13 mentions without citation

Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation.
Shrestha et al. (2018)
12 more