› 3lyi

X-ray diffraction
2.1Å resolution

PWWP Domain of Human Bromodomain-Containing Protein 1

Released:
DOI: 10.2210/pdb3lyi/pdb
PDB entry 3lyi coloured by chain, front view.
PDB entry 3lyi coloured by chain, side view.
PDB entry 3lyi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and histone binding ability characterizations of human PWWP domains.
Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, Min J
PLoS One 6 e18919 (2011)
PMID: 21720545

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 14.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95696 (Residues: 925-1049; Coverage: 12%)
Gene names: BRD1, BRL, BRPF2
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.

Ligands and Environments

1 bound ligand:
Ligand OCS 1 x OCS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 45.029Å b: 46.085Å c: 130.712Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.276
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Perceiving the epigenetic landscape through histone readers.
Musselman et al. (2012)
27 more

3 mentions without citation

PWWP domains and their modes of sensing DNA and histone methylated lysines.
Rona et al. (2016)
2 more