3m17

X-ray diffraction
2.6Å resolution

Crystal structure of human FcRn with a monomeric peptide inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-157342 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
IgG receptor FcRn large subunit p51 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 267 amino acids
Theoretical weight: 29.72 KDa
Source organism: Homo sapiens
Expression system: Cricetinae
UniProt:
  • Canonical: P55899 (Residues: 24-290; Coverage: 78%)
Gene names: FCGRT, FCRN
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Cricetinae
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
monomeric peptide inhibitor Chains: I, J, K, L
Molecule details ›
Chains: I, J, K, L
Length: 15 amino acids
Theoretical weight: 1.54 KDa

Ligands and Environments

No bound ligands
3 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: C2221
Unit cell:
a: 114.32Å b: 118.3Å c: 248.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.261 0.325
Expression system: Cricetinae