3m1b

X-ray diffraction
3.1Å resolution

Crystal structure of human FcRn with a dimeric peptide inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-157342 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
IgG receptor FcRn large subunit p51 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 267 amino acids
Theoretical weight: 29.72 KDa
Source organism: Homo sapiens
Expression system: Cricetinae
UniProt:
  • Canonical: P55899 (Residues: 24-290; Coverage: 78%)
Gene names: FCGRT, FCRN
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Cricetinae
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
DIMERIC PEPTIDE INHIBITOR Chains: I, J
Molecule details ›
Chains: I, J
Length: 16 amino acids
Theoretical weight: 1.67 KDa

Ligands and Environments

No bound ligands
3 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 68.05Å b: 158.431Å c: 82.539Å
α: 90° β: 90.11° γ: 90°
R-values:
R R work R free
0.318 0.314 0.397
Expression system: Cricetinae