› 3mdf

X-ray diffraction
1.85Å resolution

Crystal structure of the RRM domain of Cyclophilin 33

Released:
DOI: 10.2210/pdb3mdf/pdb
PDB entry 3mdf coloured by chain, front view.
PDB entry 3mdf coloured by chain, side view.
PDB entry 3mdf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.
Hom RA, Chang PY, Roy S, Musselman CA, Glass KC, Selezneva AI, Gozani O, Ismagilov RF, Cleary ML, Kutateladze TG
J Mol Biol 400 145-54 (2010)
PMID: 20460131

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194001 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase E Chains: A, B
Molecule details ›
Chains: A, B
Length: 85 amino acids
Theoretical weight: 9.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UNP9 (Residues: 1-83; Coverage: 28%)
Gene names: CYP33, PPIE
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: C2
Unit cell:
a: 85.84Å b: 40.52Å c: 65.66Å
α: 90° β: 127.06° γ: 90°
R-values:
R R work R free
0.21 0.21 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Handpicking epigenetic marks with PHD fingers.
Musselman et al. (2011)
9 more

8 mentions without citation

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.
Thapar R. (2015)
7 more