› 3mdy

X-ray diffraction
2.05Å resolution

Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189

Released:
DOI: 10.2210/pdb3mdy/pdb
PDB entry 3mdy coloured by chain, front view.
PDB entry 3mdy coloured by chain, side view.
PDB entry 3mdy coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Sanvitale C, Mahajan P, Daga N, Cooper C, Krojer T, Alfano I, Knapp S, von Delft F, Weigelt J, Arrowsmith CH, Edwards AM, Bountra C, Bullock A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126192 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bone morphogenetic protein receptor type-1B Chains: A, C
Molecule details ›
Chains: A, C
Length: 337 amino acids
Theoretical weight: 38.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00238 (Residues: 168-502; Coverage: 69%)
Gene name: BMPR1B
Sequence domains:
Structure domains:
Peptidyl-prolyl cis-trans isomerase FKBP1A Chains: B, D
Molecule details ›
Chains: B, D
Length: 109 amino acids
Theoretical weight: 12.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62942 (Residues: 1-108; Coverage: 100%)
Gene names: FKBP1, FKBP12, FKBP1A
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

1 bound ligand:
Ligand LDN 2 x LDN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 65.41Å b: 80.01Å c: 183.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.255
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

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